2099 ADAM9 Antibody #2099

"上海博耀生物销售ADAM9 Antibody #2099，CST原装品质，价格优惠，订购ADAM9 Antibody #2099，详情请咨询销售人员！产品详细参数

"上海博耀生物销售ADAM9 Antibody #2099，CST原装品质，价格优惠，订购ADAM9 Antibody #2099，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：ADAM9 Antibody #2099
货号：2099
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2099S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R Mk	Endogenous	100 pro-ADAM9-L, 80 ADAM9-L	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： ADAM9 Antibody detects endogenous levels of total ADAM9 protein, unprocessed and active forms. The antibody does not recognize the carboxy terminally truncated short form of ADAM9. In some cell types, the antibody cross-reacts with a 50 kDa band of unknown origin.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human ADAM9. Antibodies are purified using protein A and peptide affinity chromatography.
抗体背景：

The ADAM (A Disintegrin and A Metalloprotease) family of multidomain membrane proteins influences cell signaling and adhesion by shedding cell surface proteins such as cytokines and growth factors, by influencing cell adhesion to the extracellular matrix (ECM), and by directly remodeling the ECM. Conserved domains in ADAM family members include a prodomain, a zinc-dependent metalloprotease domain, a disintegrin domain, a cysteine-rich domain, an EGF-like sequence, and a short cytoplasmic tail (1,2).The prodomain is thought to aid in protein folding. Disintegrin and cysteine-rich domains mediate adhesion, at least in part, through binding to integrins. Phosphorylation of the cytoplasmic tail as well as its interaction with other signaling proteins may influence intra- and extracellular signaling (1). ADAM9 is widely distributed and has been shown to affect migration in skin keratinocytes (3,4). Research studies have shown that ADAM9 is overexpressed in prostate cancer (5), pancreatic cancer (6), gastric cancer (7), and has been linked to invasion and metastasis in small cell lung cancer (8). Research has also shown that an alternatively spliced short (50 kDa) form of ADAM9 containing protease activity is involved in tumor cell invasion (9).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab103646/Anti-BRDG 1 antibody
ab102993/Anti-C1orf77 antibody
Anti-AAT/Tryptaseα-1抗胰蛋白酶抗体
ab104267/Anti-FTSJ2 antibody
ab102586/Anti-DMRT3 antibody
ab104156/Anti-Bax antibody
Anti-MLH1/hMLH 1错配修复蛋白1抗体
Anti-PSCA前列腺干细胞抗原抗体
ab101459/Anti-CTR9 antibody
Anti-AGER晚期糖基化终末产物特异性受体抗体
ab104110/Anti-ATP1B4 antibody
ab103656/Anti-CK068 antibody
ab100806/Anti-FOXM1 antibody
ab102951/Anti-EXOC1 antibody
Anti-Leptin receptor(long)瘦素受体抗体（长）
ab103961/Anti-B9D2 antibody"
本页产品地址：http://www.geilan.com/sell/show-3242165.html