2070 ENPP1 Antibody (Human Specific) #2070

"上海博耀生物销售ENPP1 Antibody (Human Specific) #2070，CST原装品质，价格优惠，订购ENPP1 Antibody (Human Specific) #2070

"上海博耀生物销售ENPP1 Antibody (Human Specific) #2070，CST原装品质，价格优惠，订购ENPP1 Antibody (Human Specific) #2070，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：ENPP1 Antibody (Human Specific) #2070
货号：2070
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2070S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H	Endogenous	140	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： ENPP1 Antibody (Human Specific) detects endogenous levels of total ENPP1 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln815 of human ENPP1. Antibodies were purified by protein A and peptide affinity chromatography.
抗体背景：

Ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) is a single-pass, type II transmembrane protein primarily involved in ATP hydrolysis at the plasma membrane. Targeting of ENPP1 to the basolateral cell surface relies on the presence of a carboxy-terminal di-leucine-based signal (1). ENPP1 plays important roles in bone mineralization and soft tissue calcification (2-5). Mutations in the corresponding ENPP1 gene cause generalized arterial calcification in infancy (GACI) and idiopathic infantile arterial calcification (IIAC) (6,7). ENPP1 inhibits insulin receptor function and overexpression of this enzyme causes insulin resistance and glucose intolerance in mice (8,9). Genetic variants of ENPP1 have been associated with obesity and type 2 diabetes (10-12).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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