2067 eIF4E (C46H6) Rabbit mAb #2067

"上海博耀生物销售eIF4E (C46H6) Rabbit mAb #2067，CST原装品质，价格优惠，订购eIF4E (C46H6) Rabbit mAb #2067，详情请咨询销

"上海博耀生物销售eIF4E (C46H6) Rabbit mAb #2067，CST原装品质，价格优惠，订购eIF4E (C46H6) Rabbit mAb #2067，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：eIF4E (C46H6) Rabbit mAb #2067
货号：2067
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2067P	40 ul (4 western blots)	询价
2067S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IHC-P	H M R Mk	Endogenous	25	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： eIF4E (C46H6) Rabbit mAb detects endogenous levels of total eIF4E protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to human eIF4E protein.
抗体背景：

Eukaryotic initiation factor 4E (eIF4E) binds to the mRNA cap structure to mediate the initiation of translation (1,2). eIF4E interacts with eIF4G, a scaffold protein that promotes assembly of eIF4E and eIF4A into the eIF4F complex (2). eIF4B is thought to assist the eIF4F complex in translation initiation. Upon activation by mitogenic and/or stress stimuli mediated by Erk and p38 MAPK, Mnk1 phosphorylates eIF4E at Ser209 in vivo (3,4). Two Erk and p38 MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for Mnk1 kinase activity (3). The carboxy-terminal region of eIF4G also contains serum-stimulated phosphorylation sites, including Ser1108, Ser1148, and Ser1192 (5). Phosphorylation at these sites is blocked by the PI3 kinase inhibitor LY294002 and by the FRAP/mTOR inhibitor rapamycin.

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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