2061 ENPP1 (L520) Antibody #2061

"上海博耀生物销售ENPP1 (L520) Antibody #2061，CST原装品质，价格优惠，订购ENPP1 (L520) Antibody #2061，详情请咨询销售人员

"上海博耀生物销售ENPP1 (L520) Antibody #2061，CST原装品质，价格优惠，订购ENPP1 (L520) Antibody #2061，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：ENPP1 (L520) Antibody #2061
货号：2061
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2061S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H R (M)	Endogenous	140 kDa (Human), 110 kDa (Rodent)	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： ENPP1 (L520) Antibody detects endogenous levels of total ENPP1 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu520 of human ENPP1. Antibodies were purified by protein A and peptide affinity chromatography.
抗体背景：

Ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) is a single-pass, type II transmembrane protein primarily involved in ATP hydrolysis at the plasma membrane. Targeting of ENPP1 to the basolateral cell surface relies on the presence of a carboxy-terminal di-leucine-based signal (1). ENPP1 plays important roles in bone mineralization and soft tissue calcification (2-5). Mutations in the corresponding ENPP1 gene cause generalized arterial calcification in infancy (GACI) and idiopathic infantile arterial calcification (IIAC) (6,7). ENPP1 inhibits insulin receptor function and overexpression of this enzyme causes insulin resistance and glucose intolerance in mice (8,9). Genetic variants of ENPP1 have been associated with obesity and type 2 diabetes (10-12).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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