2060 Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb #2060

"上海博耀生物销售Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb #2060，CST原装品质，价格优惠，订购Phospho-PKC (pan)

"上海博耀生物销售Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb #2060，CST原装品质，价格优惠，订购Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb #2060，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb #2060
货号：2060
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2060S	100 ul (10 western blots)	询价
2060L	300 ul (30 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M R Mk	Endogenous	76 to 85	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb detects endogenous levels of PKC alpha, beta I, beta II, gamma, delta, epsilon, eta, theta and iota isoforms only when phosphorylated at a residue homologous to threonine 410 of human PKCzeta.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr410 of human PKC zeta.
抗体背景：

Activation of protein kinase C (PKC) is one of the earliest events in a cascade that controls a variety of cellular responses, including secretion, gene expression, proliferation, and muscle contraction (1,2). PKC isoforms belong to three groups based on calcium dependency and activators. Classical PKCs are calcium-dependent via their C2 domains and are activated by phosphatidylserine (PS), diacylglycerol (DAG), and phorbol esters (TPA, PMA) through their cysteine-rich C1 domains. Both novel and atypical PKCs are calcium-independent, but only novel PKCs are activated by PS, DAG, and phorbol esters (3-5). Members of these three PKC groups contain a pseudo-substrate or autoinhibitory domain that binds to substrate-binding sites in the catalytic domain to prevent activation in the absence of cofactors or activators. Control of PKC activity is regulated through three distinct phosphorylation events. Phosphorylation occurs in vivo at Thr500 in the activation loop, at Thr641 through autophosphorylation, and at the carboxy-terminal hydrophobic site Ser660 (2). Atypical PKC isoforms lack hydrophobic region phosphorylation, which correlates with the presence of glutamic acid rather than the serine or threonine residues found in more typical PKC isoforms. The enzyme PDK1 or a close relative is responsible for PKC activation. A recent addition to the PKC superfamily is PKCμ (PKD), which is regulated by DAG and TPA through its C1 domain. PKD is distinguished by the presence of a PH domain and by its unique substrate recognition and Golgi localization (6). PKC-related kinases (PRK) lack the C1 domain and do not respond to DAG or phorbol esters. Phosphatidylinositol lipids activate PRKs, and small Rho-family GTPases bind to the homology region 1 (HR1) to regulate PRK kinase activity (7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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