2047 CENP-A (C5H3) Rabbit mAb (Mouse Specific) #2047

"上海博耀生物销售CENP-A (C5H3) Rabbit mAb (Mouse Specific) #2047，CST原装品质，价格优惠，订购CENP-A (C5H3) Rabbit mAb (M

"上海博耀生物销售CENP-A (C5H3) Rabbit mAb (Mouse Specific) #2047，CST原装品质，价格优惠，订购CENP-A (C5H3) Rabbit mAb (Mouse Specific) #2047，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：CENP-A (C5H3) Rabbit mAb (Mouse Specific) #2047
货号：2047
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2047S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	M	Endogenous	17	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： CENP-A (C5H3) Rabbit mAb detects endogenous levels of total mouse CENP-A protein. This antibody does not cross-react with other histone proteins, including Histone H3.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the amino terminus of mouse CENP-A protein.
抗体背景：

Modulation of chromatin structure plays a critical role in the regulation of transcription and replication of the eukaryotic genome. The nucleosome, made up of four core histone proteins (H2A, H2B, H3, and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regulating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modulate chromatin structure (1). CENP-A, also known as the chromatin-associated protein CSE4 (capping-enzyme suppressor 4-p), is an essential histone H3 variant that replaces canonical histone H3 in centromeric heterochromatin (2). The greatest divergence between CENP-A and canonical histone H3 occurs in the amino-terminal tail of the protein, which binds linker DNA between nucleosomes and facilitates proper folding of centromeric heterochromatin (3). The amino-terminal tail of CENP-A is also required for recruitment of other centromeric proteins (CENP-C, hSMC1, hZW10), proper kinetochore assembly and chromosome segregation during mitosis (4). Additional sequence divergence in the histone fold domain is responsible for correct targeting of CENP-A to the centromere (5). Many of the functions of CENP-A are regulated by phosphorylation (6,7). Aurora A-dependent phosphorylation of CENP-A on Ser7 during prophase is required for proper targeting of Aurora B to the inner centromere in prometaphase, proper kinetochore/microtubule attachment and proper alignment of chromosomes during mitosis (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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