2045 XIAP (3B6) Rabbit mAb #2045

"上海博耀生物销售XIAP (3B6) Rabbit mAb #2045，CST原装品质，价格优惠，订购XIAP (3B6) Rabbit mAb #2045，详情请咨询销售人员

"上海博耀生物销售XIAP (3B6) Rabbit mAb #2045，CST原装品质，价格优惠，订购XIAP (3B6) Rabbit mAb #2045，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：XIAP (3B6) Rabbit mAb #2045
货号：2045
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2045P	40 ul (4 western blots)	询价
2045S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H Mk	Endogenous	53	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： XIAP (3B6) Rabbit mAb detects endogenous levels of XIAP. No cross reactivity was observed with other IAP family members.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to a region surrounding serine 245 of human XIAP.
抗体背景：

The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain (1,2). Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression (3-5). In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9 (5,6). In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase (2).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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