2036 Cleaved Lamin A (Small Subunit) (30H5) Mouse mAb #2036

"上海博耀生物销售Cleaved Lamin A (Small Subunit) (30H5) Mouse mAb #2036，CST原装品质，价格优惠，订购Cleaved Lamin A (Sma

"上海博耀生物销售Cleaved Lamin A (Small Subunit) (30H5) Mouse mAb #2036，CST原装品质，价格优惠，订购Cleaved Lamin A (Small Subunit) (30H5) Mouse mAb #2036，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Cleaved Lamin A (Small Subunit) (30H5) Mouse mAb #2036
货号：2036
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
2036S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IF-IC	H M R	Endogenous	28	Mouse IgG1

Applications Key:  W=Western Blotting  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Cleaved Lamin A (Small Subunit) (30H5) Mouse mAb detects endogenous levels of the small fragment of lamin A (and lamin C) resulting from cleavage at aspartic acid 230. The antibody does not cross-react with full length lamin A or C.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to amino-terminal residues surrounding Asp230 of human lamin A.
抗体背景：

Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization (1-3). Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment (3,4). The cleavage of lamins results in nuclear disregulation and cell death (5,6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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