2031 Cleaved Lamin A (Asp230) Antibody #2031

"上海博耀生物销售Cleaved Lamin A (Asp230) Antibody #2031，CST原装品质，价格优惠，订购Cleaved Lamin A (Asp230) Antibody #

"上海博耀生物销售Cleaved Lamin A (Asp230) Antibody #2031，CST原装品质，价格优惠，订购Cleaved Lamin A (Asp230) Antibody #2031，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Cleaved Lamin A (Asp230) Antibody #2031
货号：2031
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2031S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R	Endogenous	45, 50	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Cleaved Lamin A (Asp230) Antibody detects endogenous levels of the large fragment of lamin A (and lamin C isotype) resulting from cleavage at aspartic acid 230. The antibody does not recognize full length lamin A.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to carboxy-terminal residues surrounding Asp230 in human lamin A. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization (1-3). Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment (3,4). The cleavage of lamins results in nuclear disregulation and cell death (5,6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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