2023 FosB (5G4) Rabbit mAb (Alexa Fluor 488 Conjugate) #2023

"上海博耀生物销售FosB (5G4) Rabbit mAb (Alexa Fluor 488 Conjugate) #2023，CST原装品质，价格优惠，订购FosB (5G4) Rabbit m

"上海博耀生物销售FosB (5G4) Rabbit mAb (Alexa Fluor 488 Conjugate) #2023，CST原装品质，价格优惠，订购FosB (5G4) Rabbit mAb (Alexa Fluor 488 Conjugate) #2023，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：FosB (5G4) Rabbit mAb (Alexa Fluor 488 Conjugate) #2023
货号：2023
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2023S	100 ul (50 tests)	询价

抗体应用：

Applications	Reactivity	Sensitivity	Isotype
F	H M Mk	Endogenous	Rabbit IgG

Applications Key:  F=Flow Cytometry
Reactivity Key:  H=Human  M=Mouse  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： FosB (5G4) Rabbit mAb (Alexa Fluor^® 488 Conjugate) detects endogenous levels of total FosB protein (both FosB and FosB2 isoforms). The antibody does not cross-react with other Fos proteins, including c-fos, FRA1 and FRA2.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human FosB. The antibody was conjugated to Alexa Fluor^® 488 under optimal conditions with an F/P ratio of 2-6.
抗体背景：

The Fos family of nuclear oncogenes includes c-Fos, FosB, Fos-related antigen 1 (FRA1), and Fos-related antigen 2 (FRA2) (1). While most Fos proteins exist as a single isoform, the FosB protein exists as two isoforms: full-length FosB and a shorter form, FosB2 (Delta FosB), that lacks the carboxy-terminal 101 amino acids (1-3). The expression of Fos proteins is rapidly and transiently induced by a variety of extracellular stimuli including growth factors, cytokines, neurotransmitters, polypeptide hormones, and stress. Fos proteins dimerize with Jun proteins (c-Jun, JunB, and JunD) to form Activator Protein-1 (AP-1), a transcription factor that binds to TRE/AP-1 elements and activates transcription. Fos and Jun proteins contain the leucine-zipper motif that mediates dimerization and an adjacent basic domain that binds to DNA. The various Fos/Jun heterodimers differ in their ability to transactivate AP-1 dependent genes. In addition to increased expression, phosphorylation of Fos proteins by Erk kinases in response to extracellular stimuli may further increase transcriptional activity (4-6). Phosphorylation of c-Fos at Ser32 and Thr232 by Erk5 increases protein stability and nuclear localization (5). Phosphorylation of FRA1 at Ser252 and Ser265 by Erk1/2 increases protein stability and leads to overexpression of FRA1 in cancer cells (6). Following growth factor stimulation, expression of FosB and c-Fos in quiescent fibroblasts is immediate, but very short-lived, with protein levels dissipating after several hours (7). FRA1 and FRA2 expression persists longer, and appreciable levels can be detected in asynchronously growing cells (8). Deregulated expression of c-Fos, FosB, or FRA2 can result in neoplastic cellular transformation; however, Delta FosB lacks the ability to transform cells (2,3).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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