2017 MSH2 (D24B5) Rabbit mAb #2017

"上海博耀生物销售MSH2 (D24B5) Rabbit mAb #2017，CST原装品质，价格优惠，订购MSH2 (D24B5) Rabbit mAb #2017，详情请咨询销售

"上海博耀生物销售MSH2 (D24B5) Rabbit mAb #2017，CST原装品质，价格优惠，订购MSH2 (D24B5) Rabbit mAb #2017，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：MSH2 (D24B5) Rabbit mAb #2017
货号：2017
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2017P	40 ul (4 western blots)	询价
2017S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IHC-P IF-IC F	H M	Endogenous	100	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)  IF-IC=Immunofluorescence (Immunocytochemistry)  F=Flow Cytometry
Reactivity Key:  H=Human  M=Mouse  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： MSH2 (D24B5) XP^® Rabbit mAb detects endogenous levels of total MSH2 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues at the amino terminus of human MSH2.
抗体背景：

The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage (1). MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex (2).Mutations in MSH2 have been found in a large proportion of hereditary non-polyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world (3). Mutations have also been associated with other sporadic tumors.

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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