2009 Phospho-β-Catenin (Ser33/37) Antibody #2009

"上海博耀生物销售Phospho-β-Catenin (Ser33/37) Antibody #2009，CST原装品质，价格优惠，订购Phospho-β-Catenin (Ser33/37)

"上海博耀生物销售Phospho-β-Catenin (Ser33/37) Antibody #2009，CST原装品质，价格优惠，订购Phospho-β-Catenin (Ser33/37) Antibody #2009，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-β-Catenin (Ser33/37) Antibody #2009
货号：2009
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2009S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H (M) (R) (X) (Z)	Endogenous	92	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  X=Xenopus  Z=Zebrafish
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-β-Catenin (Ser33/37) Antibody detects endogenous levels of β-catenin only when phosphorylated at Ser33 and Ser37.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser33 and Ser37 of human β-catenin. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

β-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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