氯乙酸(MCAA)作为活性化合物,是一种重要的有机精细化工原料,广泛应用于农药(除莠剂)、医药、染料、油田化学品(钻井液)、造纸化学品、塑料助剂(塑料稳定剂)、纺织助剂、表面活性剂、电镀、香料香精等领域。其大用途是生产羧甲基纤维素(CMC),其次是生产巯基乙酸。
随着技术进步和发展,氯乙酸新的应用领域逐渐得到开发,前景十分广阔。据统计,2005年氯乙酸主要用途为:羧甲基纤维索(CMC)占33%,除草剂2,4-二氯苯氧基乙酸(2,4-D)和乐果占21%,其他用途中,巯基乙酸占14%,两性表面活性剂占12%,氰基酯和丙二酸盐占11%。在欧洲,用于 CMC占40%以上,美国用于表面活性剂占20%以上。
氯乙酸的测定有以下几种方法：1.化学滴定法；2.酯化气相色谱法。以上方法操作复杂，不环保，酯化法又存在转化率的问题。
滕州市浩瀚色谱仪器技术服务有限公司，，研发出液相色谱法测定氯乙酸及杂质二氯乙酸，乙酸等杂质的含量，二氯乙酸出峰在氯乙酸之前，无覆盖，分离好，结果准确。
液相柱测定氯乙酸 图片：



Determination of chloroacetic acid by liquid column
Determination of chloroacetic acid by liquid column

Stationary phase: dedicated
Specification: HH-LYS2019


As an active compound, chloroacetic acid (MCAA) is an important organic fine chemical raw material widely used in pesticides (eliminating agents), medicines, dyes, oilfield chemicals (drilling fluids), paper chemicals, plastic additives (plastics). Stabilizers), textile auxiliaries, surfactants, electroplating, perfume flavors and other fields. Its greatest use is in the production of carboxymethyl cellulose (CMC), followed by the production of thioglycolic acid.
With the advancement and development of technology, new applications of chloroacetic acid have been gradually developed and the prospects are very broad. According to statistics, the main uses of chloroacetic acid in 2005 were: carboxymethyl cellulose (CMC) accounted for 33%, herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) and dimethoate accounted for 21%. In the application, thioglycolic acid accounted for 14%, amphoteric surfactant accounted for 12%, and cyano ester and malonate accounted for 11%. In Europe, CMC accounts for more than 40%, and in the United States, surfactants account for more than 20%.
There are several methods for the determination of chloroacetic acid: 1. Chemical titration; 2. Esterification gas chromatography. The above method is complicated in operation, not environmentally friendly, and the esterification method has a problem of conversion rate.
Tengzhou Haohao Chromatography Instrument Technology Service Co., Ltd., with the advancement of the times, developed high performance liquid chromatography for the determination of chloroacetic acid and impurities such as dichloroacetic acid, acetic acid and other impurities, the peak of dichloroacetic acid before chloroacetic acid, no coverage, Separated and the results are accurate. This column is a vast chromatographic, exclusive development, and is currently applying for patent protection.

Determination of chloroacetic acid by liquid column