JN0591 重组人信号素

我公司致力于为客户提供高纯度、低成本的活性重组蛋白，包括重组人信号素在内的各类受体、细胞因子、生长因子、转录因子、激素、酶、毒性蛋白、病毒抗原等。...

特别提示：包括重组人信号素(Semaphorin )(Sema)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人信号素(Semaphorin )(Sema)
英文名称：Recombinant Human Semaphorin
产品货号：JN0591
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Glu23-Thr765在C端含有His标签。

Semaphorin 质量控制：＞95%(还原性SDS-PAGE)

Semaphorin 制剂：冻干品

Semaphorin 保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Semaphorin 复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Semaphorin ：
Semaphorin- (SEMA) is a member of the Semaphorin family of axon guidance molecules. SEMA is a 140 kDa protein. Class 5 Semaphorins are type I transmembrane glycoproteins with an N- terminal Sema domain and multiple juxtamembrane type 1 Thrombospondin (TSP) repeats within their extracellular domains. SEMA is expressed in neuroepithelial cells surrounding retinal axons, oligodendrocytes, the base of limb buds, the mesoderm surrounding cranial vessels , and the cardiac atrial septum and endocardial cushions, Human SEMA cDNA encodes a signal sequence, a extracellular domain (ECD), a transmembrane sequence and an cytoplasmic portion. SEMA mutations have been implicated in the genetic syndrome,cri-du-chat,while some polymorphisms may increase risk for neurodegenerative diseases such as Parkinson. The expression of SEMA may be upregulated in metastatic cancer cells and downregulated in autism.

根据您的关注的重组人信号素(Semaphorin )(Sema)，重组Sema，重组人Sema，重组人信号素，rSema，Recombinant Human Semaphorin ，rhSema，重组人Semaphorin ，重组信号素，重组Semaphorin ，您可能还对以下产品有需求：

货号	名称	规格
JN0227	重组人LR3-IGF1	10μg|50μg|500μg|1mg
JN0235	重组人VEGFD(血管内皮生长因子D)(带His标签)	10μg|50μg|500μg|1mg
JN0378	重组人白介素IL-13(白细胞介素13)	10μg|50μg|500μg|1mg
JN0472	重组小鼠TNFRSF1B	10μg|50μg|500μg|1mg
JN0497	重组小鼠TL1A(TNFSF15)	10μg|50μg|500μg|1mg
JN2000	重组人γ谷氨酰氨环化转移酶(GGACT)	10μg|50μg|500μg|1mg

关注重组人信号素(Semaphorin )(Sema)，重组Sema，重组人Sema，重组人信号素，rSema，Recombinant Human Semaphorin ，rhSema，重组人Semaphorin ，重组信号素，重组Semaphorin 的同时，为您推荐更多您可能感兴趣的产品：



名称：重组人白介素IL-36α(白细胞介素36α)
货号：JN0352
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，目的基因编码的Met1-Phe158表达纯化而来。

IL-36 alpha/IL-1F6质量控制：＞95%(还原性SDS-PAGE)。

IL-36 alpha/IL-1F6制剂：冻干品

IL-36 alpha/IL-1F6保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

IL-36 alpha/IL-1F6复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于IL-36 alpha/IL-1F6：
Human Interleukin-36α (IL-36α) is a secreted cytokine that belongs to the Interleukin 1 cytokine family. IL-36α is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36α is the only IL-1 family member found to be expressed on T-cells. IL-36α and IL-1F8 are involved in the regulation of adipose tissue gene expression. importantly, IL-36α inhibits PPARγ expression, which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine. IL-36α, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36α may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.

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