JN1588 重组人Importinβ1

我公司致力于为客户提供高纯度、低成本的活性重组蛋白，包括重组人Importinβ1在内的各类受体、细胞因子、生长因子、转录因子、激素、酶、毒性蛋白、病毒抗原等。...

特别提示：包括重组人importinβ1(KPNB1)(核转运受体蛋白)(输入蛋白β1)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人importinβ1(KPNB1)(核转运受体蛋白)(输入蛋白β1)
英文名称：Recombinant Human importin Subunit Beta-1
产品货号：JN1588
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Ala876在N端含有His标签。

KPNB1质量控制：＞95%(还原性SDS-PAGE)

KPNB1制剂：液体

KPNB1保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于KPNB1：
importin subunit beta-1(KPNB1) is a member of the importin beta family. KPNB1 contains 1 importin N-terminal domain and 19 HEAT repeats. It is involved in nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. Its functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. The import of proteins containing a classical nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits. Each of these subunits is part of the karyopherin family of proteins. importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. It mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5.

根据您的关注的重组人importinβ1(KPNB1)(核转运受体蛋白)(输入蛋白β1)，重组核转运受体蛋白，rimportinβ1，rKPNB1，重组importin Subunit Beta-1，重组人importin Subunit Beta-1，重组人核转运受体蛋白，Recombinant Human importin Subunit Beta-1，重组importinβ1，rhimportinβ1，重组人importinβ1，重组人输入蛋白β1，重组KPNB1，重组人KPNB1，重组输入蛋白β1，rhKPNB1，您可能还对以下产品有需求：

货号	名称	规格
JN0224	重组人VEGF-A(VEGF165)	10μg|50μg|500μg|1mg
JN0431	重组小鼠干扰素γ	10μg|50μg|500μg|1mg
JN1898	重组人甲状旁腺素(PTH)	10μg|50μg|500μg|1mg
JN1925	重组人β-防御素4A	10μg|50μg|500μg|1mg
JN1970	重组人子宫球蛋白相关蛋白1(UGRP1)	10μg|50μg|500μg|1mg
JN0609	重组人PDILT	10μg|50μg|500μg|1mg

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名称：重组人SHH(音猬因子)
货号：JN0229
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，目的基因编码的Cys24-Gly197表达纯化而来。

SHH质量控制：＞95%(还原性SDS-PAGE)。

SHH制剂：冻干品

SHH保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

SHH复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于SHH：
Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic development. SHH is expressed in various embryonic tissues and plays critical roles in regulating the patterning of many systems, such as limbs and brain. SHH also plays an important role in adult, including the division of adult stem cells and the development of certain cancers and other diseases. Human SHH is expressed as a 45kDa precursor, and undergoes a series of processing during secretion. After the removal of the signal peptide, a protease within the C-terminal domain catalyzes the cleavage of SHH into a 20 kDa N-terminal signaling domain (SHH-N) and a 25 kDa C-terminal domain (SHH-C). SHH-N has the “all signaling” capability. SHH-N binds to the 12 pass transmembrane protein Patched (Ptc) on cell surface, which releases the repression of the activity of Smoothened (Smo), a G-protein coupled receptor, by Ptc.

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