L10107 AG-1478

北京百奥莱博供应的AG-1478用于科研目的，我公司专注于抑制剂激活剂产品的研发、生产和供应，为您提供的AG-1478质量可靠，批间差小，且价格公道，热切盼望您选购我们的产品。...

特别提示：包括AG-1478(Tyrphostin AG-1478)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：AG-1478(Tyrphostin AG-1478)
英文名称：AG-1478(Tyrphostin AG-1478)
产品货号：L10107
产品规格：5mg|10mg|25mg|50mg

属性

CAS号	153436-53-4
分子式	C16H14ClN3O2
分子量	315.75
溶解性	25℃:DMSO 25mg/mL;Water<1 mg/mL;Ethanol 13 mg/mL
存贮条件	储存温度-20℃
密度	1.3370

描述

产品介绍	AG-1478(NSC 693255)是EGFR选择性抑制剂，IC50为3 nM，对HER2-Neu，PDGFR，Trk，Bcr-Abl和InsR无活性。
备注	AG-1478(Tyrphostin AG-1478) is a selectiveEGFRinhibitor withIC50of 3 nM,almost no activity on HER2-Neu,PDGFR,Trk,Bcr-Abl and InsR.
生化机理	AG1478 inhibited EGFR phosphorylation in CNE2 cells without reduced expression of EGFR protein.The activation of Akt and MAPK which are downstream molecules of EGFR signaling pathway,were also inhibited by AG1478.Although AG 1478 inhibited cell growth,DNA synthesis,EGFR tyrosine kinase activity,and receptor autophosphorylation of each cell line in a dose-dependent manner,it was significantly more potent in U87MG.delta EGFR cells than in the other two cell lines. in vivo:At the lowest dose,plasma drug levels after the cessation of infusion declined with a half-life of approximately 43min.EGFR activity,measured both by autophosphorylation and downstream signalling,was inhibited in a dose-dependent manner by injection of AG1478 in mice bearing xenografts of the human glioblastoma cell line U87MG
别名	酪氨酸激酶抑制剂AG 1478;N-(3-氯苯基)-6,7-二甲氧基-4-氨基喹唑啉;(3-氯苯基)(6,7-二甲氧基喹唑啉-4-基)胺;Tyrphostin AG-1478;AG 1478;NSC 693255;AG1478;N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine;3-chlorophenyl)(6,7-dimethoxyquinazolin-4-yl)amine

根据您的关注的AG-1478(Tyrphostin AG-1478)(153436-53-4)(≥98%)，3-chlorophenyl)(6,7-dimethoxyquinazolin-4-yl)amine，AG-1478，(3-氯苯基)(6,7-二甲氧基喹唑啉-4-基)胺，NSC 693255，153436-53-4，N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine，AG 1478，AG-1478(Tyrphostin AG-1478)，N-(3-氯苯基)-6,7-二甲氧基-4-氨基喹唑啉，AG1478，酪氨酸激酶抑制剂AG 1478，Tyrphostin AG-1478，L10107，百奥莱博，，，您可能还对以下产品有需求：


YT339 sGC抑制剂(NS-2028) 1mg
M00134 mTORC抑制剂(Torin1) 1mL(10mM)|5mg|10mg|50mg|100mg
M00262 磷酸酶抑制剂(PP1活性抑制剂)(Salubrinal) 1mL(10mM)|5mg|10mg|25mg|50mg|100mg
M00290 Syk抑制剂(GS-9973) 1mL(10mM)|5mg|10mg|50mg|100mg|200mg
M00471 ASK1抑制剂(Selonsertib) 1mL(10mM)|5mg|10mg|50mg|100mg|200mg
M00636 CDK/TRK抑制剂(PHA-848125) 1mL(10mM)|5mg|10mg|50mg|100mg
M01002 HIF-1抑制剂(KC7F2) 1mL(10mM)|5mg|10mg|50mg|100mg

关注AG-1478(Tyrphostin AG-1478)(153436-53-4)(≥98%)，3-chlorophenyl)(6,7-dimethoxyquinazolin-4-yl)amine，AG-1478，(3-氯苯基)(6,7-二甲氧基喹唑啉-4-基)胺，NSC 693255，153436-53-4，N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine，AG 1478，AG-1478(Tyrphostin AG-1478)，N-(3-氯苯基)-6,7-二甲氧基-4-氨基喹唑啉，AG1478，酪氨酸激酶抑制剂AG 1478，Tyrphostin AG-1478，L10107，百奥莱博，，的同时，为您推荐更多您可能感兴趣的产品：

货号	名称	规格
YT933	BET抑制剂(GSK525762)	10mM×0.2ml|5mg|25mg
KFS287	Catechin hydrate(抗氧化剂)	0.5g
M00115	多靶点激酶抑制剂(Ponatinib)	1mL(10mM)|10mg|50mg|100mg
M00251	ROCK2抑制剂(SLx-2119)	1mL(10mM)|2mg|5mg|10mg|50mg|100mg
M00262	磷酸酶抑制剂(PP1活性抑制剂)(Salubrinal)	1mL(10mM)|5mg|10mg|25mg|50mg|100mg
M00401	ROCK-II/PKA/PKG/PKC/MLCK抑制剂	1mL(10mM)|100mg|200mg|500mg

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